{"id":152,"date":"2019-01-12T00:10:00","date_gmt":"2019-01-11T23:10:00","guid":{"rendered":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/?p=152"},"modified":"2019-12-11T01:41:44","modified_gmt":"2019-12-11T00:41:44","slug":"enterovirus-assembling","status":"publish","type":"post","link":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/?p=152","title":{"rendered":"Enterovirus Assembling"},"content":{"rendered":"\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Entero virus V71 capsid assemble anim white 3Dc\" width=\"580\" height=\"326\" src=\"https:\/\/www.youtube.com\/embed\/kNPNC5PL-L0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><figcaption>Animation of enterovirus V71 capsid assembling<\/figcaption><\/figure>\n\n\n\n<p> The capsids of spherical (icosahedral) viruses are constructed of  multiples of 60 subunits. The question of how these polymers assemble is  basic to understanding the viral life cycle.<\/p>\n\n\n\n<p> A formalism describing  virus assembly as an equilibrium between coat protein subunits, assembly  intermediates and intact virus is presented. This equilibrium model of  virus assembly is consistent with experimental observations of virus  assembly. At equilibrium, either intact virus or free subunits are  dominant species, assembly intermediates are predicted to be found only  in trace concentrations. <\/p>\n\n\n\n<p> Modest intersubunit interaction energies result in a  very stable capsid; consequently, a small change in this interaction  energy can result in a considerable change in the capsid-subunit equilibrium. Some possible effects of nucleation and protein-nucleic  acid interactions on virus assembly and capsid morphology are  considered. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>The capsids of spherical (icosahedral) viruses are constructed of multiples of 60 subunits. The question of how these polymers assemble is basic to understanding the viral life cycle. A formalism describing virus assembly as an equilibrium between coat protein subunits, assembly intermediates and intact virus is presented. This equilibrium model of virus assembly is consistent [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,17,5],"tags":[],"_links":{"self":[{"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=\/wp\/v2\/posts\/152"}],"collection":[{"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=152"}],"version-history":[{"count":3,"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=\/wp\/v2\/posts\/152\/revisions"}],"predecessor-version":[{"id":155,"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=\/wp\/v2\/posts\/152\/revisions\/155"}],"wp:attachment":[{"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=152"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tresddos.com\/ramonandrade\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}